Apoptosis Inhibition by the Human DEK Oncoprotein Involves Interference with p53 Functions

Characterisation of the proto-oncoprotein DEK

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Intercellular trafficking of the nuclear oncoprotein DEK.

DEK is a biochemically distinct, conserved nonhistone protein that is vital to global heterochromatin integrity. In addition, DEK can be secreted and function as a chemotactic, proinflammatory factor. Here we show that exogenous DEK can penetrate cells, translocate to the nucleus, and there carry out its endogenous nuclear functions. Strikingly, adjacent cells can take up DEK secreted from syno...

Delayed myocardial preconditioning by alpha1-adrenoceptors involves inhibition of apoptosis.

OBJECTIVE Previous studies have demonstrated that alpha1-adrenoceptor activation increases myocardial resistance to ischemic injury 24 hours later. Here we tested the hypothesis that delayed protection is associated with limited infarction and involves altered expression of pro-apoptotic and/or anti-apoptotic proteins. METHODS Rabbits were treated with phenylephrine or an equivalent volume of...

High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length.

Poly(ADP-ribose) polymerase-1 (PARP-1) is a molecular DNA damage sensor that catalyzes the synthesis of the complex biopolymer poly(ADP-ribose) (PAR) under consumption of NAD(+). PAR engages in fundamental cellular processes such as DNA metabolism and transcription and interacts noncovalently with specific binding proteins involved in DNA repair and regulation of chromatin structure. A factor i...

The DEK oncoprotein is upregulated by multiple leukemia-associated fusion genes.